On the limitations of my current lifestyle

Lately, I have been frustrated with my life.  My job, my hobbies, my cats, my house... My reaction to this frustration has been a desire to just pick up and go somewhere else.  But I have to wonder if that will improve anything, or if I'll end up in the same situation, but somewhere else and with fewer friends and family. 

Moving would allow both Gabb and me to explore different career options.  It would also give us a chance to live somewhere we know will have interesting activities or geography.  However, it wouldn't change the fact that we have two cats, full time jobs with around three weeks vacation, and a 40 hour workweek.  It would also result in another housing commitment, though we could rent or buy as wanted. 

The limitation of all this, of course, is that almost all fun and entertainment that lasts more than a day or two requires planning and notice.  And it can only last as long as I don't run out of vacation time.  So how can I maximize the benefits and minimize the limitations?